http://genesdev.cshlp.org/content/9/8/984.full.pdf WebSTAT3 is constitutively phosphorylated in various cancers and drives gene expression from GAS-containing promoters to promote tumorigenesis. Recently, roles for …
Targeting STAT3 in Cancer Immunotherapy - Molecular Cancer
WebMar 14, 2013 · STAT3–STAT3 dimerization, which involves reciprocal binding of the STAT3-SH2 domain to phosphorylated tyrosine-705 (Y-705), is required for STAT3 nuclear translocation, DNA binding, and transcriptional regulation of downstream target genes. WebApr 13, 2024 · Once activated by various types of stimuli, phosphorylated STAT3 translocate into the nucleus to initiate transcription via binding to the promoter sequence of target genes. Moreover, it has been reported that STAT3 nuclear import may be independently of its phosphorylation and mediated by specific import carrier-α3 [ 81 ]. healthier together step a
STAT3 Gene - GeneCards STAT3 Protein STAT3 Antibody
WebMay 9, 2024 · We introduced a lentiviral construct with 7-repeat Stat3-binding sequence to drive Renilla luciferase into ES cells, which can be used as a reporter to detect Stat3 activation by noninvasive bioluminescence imaging. Using this ES cells, we investigated the role of Stat3 activation in ground state maintenance. WebAug 21, 2024 · The final eluate is purified DNA, which was analyzed by RT-qPCR for NF-κB or STAT3 binding to the promoter sequences of IL6 target gene, and normalized to 3% of the input. Validated primers from previous studies were used, and their sequences were: (-167) IL6-CHIP-NF-κB-F: 5′-CCTCACCCTCCAACAAAGAT-3′ and ... WebMay 31, 2011 · When STAT3 is elevated in tumor cells and tumor-infiltrating immune cells, persistently activated NF-κB interacts with STAT3 and preferentially binds to genes with STAT3-binding site (s) in promoters. A large number of NF-κB downstream genes associated with oncogenesis and chronic inflammation contain STAT3 DNA-binding site … healthier together unwell baby