WebPeptide-MHC complexes have limited life spans at 37°C and therefore MHC I molecules provide a dynamic display of endogenously produced peptides. pMHC complexes can be obtained by refolding of denatured heavy and light (β2m) chains in … WebOct 22, 2015 · Indeed despite the small amount of pMHC molecules per spot on the array, and the low frequency of pMHC availability (estimated to be less than 2% of the total pMHC spotted), the pMHC array can detect T cell populations in patients which exist at clinically-relevant frequencies (0.1% of the total CD8 + population), with similar sensitivity to ...
Empty peptide-receptive MHC class I molecules for efficient …
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