Bobcat339 selleck
WebSelleck Chemicals Bobcat339 hydrochloride 5mg 696800141 S6682 2436747-44-1 297.740 C16H12ClN3O. Catalog No. NC2199358. $506.46 / Each of 1. Due to product restrictions, please Sign In to purchase or view availability for this product. This item is not returnable. View return policy. Provide Content Correction.
Bobcat339 selleck
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WebJan 31, 2024 · We identify a promising cytosine-based lead compound, Bobcat339, that has mid-μM inhibitor activity against TET1 and TET2, but does not inhibit the DNA … WebDescription. Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5 …
WebBobcat339 is a cell penetrant, potent and selective inhibitor of TET1 and TET2 [Ten-eleven translocation methylcytosine dioxygenase (TET) 1 and 2] that reduces content of 5 … WebBobcat 339 is a cytosine derivative that was originally found to be an inhibitor of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) and TET2 (IC 50 s = 33 and 73 µM, …
WebBobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5 … Web7139339 Tilt Cylinder Seal Kit: Bobcat
WebJan 6, 2024 · This underlines the current interest in developing targeted pharmaceutical inhibitors of these enzymes. Here, we will survey the complexity of TET roles in cancer, and its hypoxic modulation, as well as highlight the potential of these enzymes as therapeutic targets. Abbreviations α-KG α-ketoglutarate 5caC 5-carboxylcytosine 5fC 5-formylcytosine
WebJan 16, 2024 · Description: Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a; Bobcat339 is a useful tool for investigation of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene … home report company glasgowWebFeb 15, 2024 · Polycystic ovary syndrome is one of the most common endocrine and metabolic gynecological disorders, of which dysfunction of ovarian granulosa cells is a key contributing factor. The aim of the present study was to explore the role of ferrostatin‑1 (Fer‑1), a ferroptosis inhibitor, in a cell injury model established by homocysteine … home repiping with pexWebBobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control. home reporting radiologyWebOct 4, 2024 · “Bobcat339 is the product of really hard work and great relationships, but there’s also a splash of good luck.” For Chua, the … hipaa privacy practices noticeWebRecently, a novel cytosine-based inhibitor of TET, Bobcat339, was reported to have mid-μM inhibitory activity against TET1 and TET2. The molecule is now sold as a TET inhibitor by several vendors. home replacement of grovia velcro coversWebBobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC 50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a. Technical Data for Bobcat339 home report downloadWebHomepage All Categories Bobcat339 1mg Bobcat339 1mg CAS# 2280037-51-4 Grade: HPLC SKU: ChemD-976-S6682-1mg-1x1-Milligram-2280037-51-4 ... hipaa privacy practices printable